NSI-189 Free Base – Powder, 1 gram

High-Purity NSI-189 Free Base Powder (1 Gram): Industrial-Grade Bulk Supply

Procuring specialized neurogenic agents in their non-salt, active molecular forms is critical for custom chemical synthesis, lipid-based delivery formulations, and targeted central nervous system research. registeredpeptides.co supplies industrial-grade NSI-189 Free Base Powder (1 Gram) engineered to support scalable enterprise procurement and commercial laboratory testing protocols.

We support chemical distributors, enterprise laboratories, and high-volume purchasers who demand strict chemical specifications, verified purity profiles, and dependable supply chain logistics.

Key Specifications & Chemical Profile

• Chemical Name: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone

• CAS Number: 1270138-41-4 (Free Base)

• Molecular Formula: $\text{C}_{22}\text{H}_{30}\text{N}_4\text{O}$

• Molecular Weight: $366.51\text{ g/mol}$

• Unit Format: 1 Gram (Pure Crystalline Powder / Free Base Form)

• Purity Rating: Verified $\ge 98\%$ via High-Performance Liquid Chromatography (HPLC)

• Grade: High-purity industrial and research reference standard

Compound Overview & Technical Mechanism

NSI-189 Free Base is a novel benzylpiperazine-aminopyridine derivative developed for its potent neurogenic activity within hippocampal structures. Unlike its phosphate salt counterpart, the Free Base form possesses higher lipophilicity and non-ionized structural characteristics at neutral pH, making it the preferred format for organic solvent solubility studies, liposomal encapsulation assays, and specialized membrane permeability testing.

In laboratory and biochemical research, NSI-189 Free Base operates through distinct cellular mechanisms:

• Hippocampal Neurogenesis Stimulation: In vitro assays indicate that NSI-189 selectively stimulates neurogenesis and synaptogenesis in human subgranular zone (SGZ) derived neural stem cells.

• Volumetric & Structural Plasticity: Demonstrates the capacity to promote dendritic spine density maturation and structural arborization in hippocampal cell preparations without direct affinity for monoamine transporters or classical neurotransmitter receptors.

• Trophic Signaling Pathway Activation: Modulates intracellular signaling cascades involved in structural remodeling, cellular survival, and synaptic plasticity.

The 1-gram pure free base powder format provides exact quantitative flexibility, allowing precise weighing and formulation across diverse analytical and assay setups.

What Industrial Chemical Users Look For

When commercial procurement managers, industrial chemists, and laboratory directors source bulk NSI-189 Free Base powder and raw chemical inventory, core specifications include:

1. Verified Chemical Purity & COA Document: Complete lot characterization via NMR, Mass Spectrometry (MS), and HPLC to confirm exact molecular structure, non-salt purity, and freedom from unreacted precursors or heavy metals.

2. Scalable Wholesale Supply: Uninterrupted supply chain pipelines capable of providing bulk raw powder shipments for industrial formulation and contract research.

3. Crystalline Integrity & Stability: Processed and packaged under controlled environmental conditions to preserve particle morphology, prevent atmospheric moisture absorption, or chemical degradation.

4. Batch-to-Batch Uniformity: Strict quality control standards guaranteeing identical melting point, solubility profiles, and purity metrics across all production lots.

5. Chain-of-Custody Logistics: Secure domestic shipping pipelines with moisture-proof, UV-protected packaging to guarantee compound integrity upon arrival.

Key Applications in Research & Industrial Settings

• Lipophilic & Permeability Assays: Evaluating passive membrane permeability and blood-brain barrier passage models using non-ionized active molecules.

• Neural Stem Cell Proliferation Studies: Measuring neurogenesis rates and cellular differentiation velocity in precursor cell cultures.

• Liposomal & Organic Solution Formulations: Utilizing the free base state for solubilization in non-aqueous vehicles and custom carrier systems.

• Analytical Reference Standard: Serving as a pure baseline reference standard for developing LC-MS/MS quantitative detection and salt-conversion protocols.

Bulk Ordering and Quality Assurance

registeredpeptides.co provides commercial clients and research facilities direct access to high-grade chemical supply backed by batch-specific analytical testing. Every production lot of NSI-189 Free Base Powder (1 Gram) undergoes third-party testing to uphold strict quality control standards.

To request current batch Certificates of Analysis (COA), inquire about custom bulk packaging, or secure tiered volume pricing, contact our chemical distribution team today.