Industrial-Grade REV-ERB Agonist for Metabolic & Circadian Research

SR-9011 is a synthetic REV-ERB agonist designed to specifically bind to REV-ERBα and REV-ERBβ nuclear receptors. By enhancing REV-ERB activity, SR-9011 modulates the expression of genes involved in circadian rhythms, lipid metabolism, glucose regulation, and cellular energy expenditure. Unlike compounds operating via androgenic pathways, SR-9011 provides researchers and chemical buyers with a distinct metabolic mechanism focused on mitochondrial biogenesis and oxygen consumption models.

At peptidesprocanada.com, we specialize in supplying high-volume, industrial-grade compounds for laboratory and commercial applications. Our SR-9011 5mg / 60 Capsules product is manufactured under strict quality control conditions to ensure uniform particle distribution, accurate dosing, and high baseline chemical purity.

Key Specifications & Technical Profile

• Chemical Name: Ethyl 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

• Synonyms: SR9011, SR 9011

• CAS Number: 1379686-29-9

• Molecular Formula: C20H24ClN3O4S

• Molecular Weight: 437.94 g/mol

• Dosage Strength: 5mg per capsule

• Quantity: 60 Capsules per container

• Purity Level: ≥ 99% (HPLC Verified)

• Form: Encapsulated Solid Powder

• Classification: Synthetic REV-ERB Nuclear Receptor Agonist

Technical Profile & Mechanism of SR-9011

SR-9011 functions as a potent, full REV-ERB agonist (IC50=790 nMIC_{50} = 790text{ nM}IC50​=790 nM for REV-ERBα and IC50=560 nMIC_{50} = 560text{ nM}IC50​=560 nM for REV-ERBβ). Its primary biochemical role involves suppressing target genes that contain REV-ERB response elements (ROREs), directly impacting core circadian transcription feedback loops.

Key advantages for industrial chemical testing and research include:

1. Targeted Nuclear Receptor Activation: Highly selective for REV-ERB proteins without cross-reacting with other nuclear receptors like PPARs or LXRs.

2. Mitochondrial Upregulation: Used in assays studying mitochondrial gene expression, oxygen consumption rates, and cellular respiration kinetics.

3. Consistent Chemical Behavior: Stable thiophene and pyrrolidine core structure allowing predictable performance in standardized solution and solid matrix assays.

Critical Standards for Commercial Chemical Procurement

Commercial buyers, institutional research managers, and chemical brokers require verifiable quality standards and transparent supply chain practices. peptidesprocanada.com delivers on all operational requirements:

• Analytical Verification (HPLC & Mass Spec): Every production run is subjected to rigorous testing to verify a minimum purity of 99%, ensuring complete freedom from synthesis impurities and organic residues.

• Automated Dosing Precision: Encapsulated utilizing high-precision volumetric solid filling systems to ensure a constant 5mg active ingredient count per unit.

• Full Documentation Package: Orders include detailed Certificates of Analysis (CoA) and up-to-date Safety Data Sheets (SDS) for compliance and safety management.

• Stability-Enriched Packaging: Packed in sealed, air-tight, UV-resistant containers designed to guard sensitive thiophene ring structures against photo-oxidation.

• Fast Canadian Domestic Shipping: Direct fulfillment across Canada ensures quick turnarounds and avoids import friction, tariffs, or custom holds.

Industrial & Laboratory Applications

SR-9011 is extensively utilized in modern biochemical, metabolic, and pharmaceutical research domains:

• Circadian Rhythm Gene Expression: Studying the transcriptional suppression of Bmal1 and Clock genes in cellular oscillator models.

• Metabolic Pathway Mapping: Evaluating liver cell lipid synthesis, glucose oxidation, and energy output under controlled exposure.

• Mitochondrial Biogenesis Assays: Measuring changes in mitochondrial density and ATP generation in skeletal muscle tissue cultures.

• Endurance & Oxygen Consumption Models: Analyzing metabolic rate increases and non-androgenic energy pathway upregulation.

Wholesale & Bulk Procurement in Canada

Whether you are securing bulk chemical inventories for large-scale institutional projects or commercial redistribution, peptidesprocanada.com provides scalable purchasing options, volume discounts, and stable domestic inventory.

Purchase SR-9011 5mg Capsules (60 Capsules) directly through peptidesprocanada.com today to ensure high chemical purity, documented quality, and reliable shipping across Canada.