Coluracetam – Powder, 1 gram

High-Purity Coluracetam Powder (1 Gram): Industrial-Grade Bulk Supply

Procuring advanced cholinergic research chemicals requires high structural fidelity, consistent crystalline formation, and comprehensive analytical documentation. registeredpeptides.co supplies industrial-grade Coluracetam Powder (1 Gram) engineered to support scalable enterprise procurement and commercial laboratory testing protocols.

We support chemical distributors, enterprise laboratories, and high-volume purchasers who demand exact chemical specifications, verified purity profiles, and dependable supply chain logistics.

Key Specifications & Chemical Profile

• Chemical Name: 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)acetamide

• Synonyms: Coluracetam, MKC-231, BCI-540

• CAS Number: 135463-81-9

• Molecular Formula: $\text{C}_{19}\text{H}_{23}\text{N}_3\text{O}_3$

• Molecular Weight: $341.41\text{ g/mol}$

• Unit Format: 1 Gram (Pure Crystalline Solid / Powder)

• Purity Rating: Verified $\ge 98\%$ via High-Performance Liquid Chromatography (HPLC)

• Grade: High-purity industrial and research reference standard

Compound Overview & Technical Mechanism

Coluracetam (MKC-231) is a synthetic research compound belonging to the racetam family, featuring a unique tetrahydrofuroquinoline core linked to a pyrrolidone acetamide structure. Developed for its potent, highly targeted interaction with central cholinergic pathways, Coluracetam operates through a distinct biological mechanism.

In laboratory and biochemical research, Coluracetam exhibits a specialized mechanism of action:

• High-Affinity Choline Uptake (HACU) Enhancer: Uniquely increases choline influx through the high-affinity choline transporter 1 (CHT1) located at presynaptic cholinergic nerve terminals.

• Choline Transporter Density Upregulation: Studies indicate that Coluracetam increases the velocity ($V_{\max}$) of choline uptake without altering receptor affinity ($K_m$), making it a primary reference standard for HACU dynamics.

• AMPA Receptor Potentiation: Demonstrates indirect modulating effects on glutamate-mediated AMPA receptor signaling pathways in hippocampal cell cultures.

The 1-gram pure powder format provides exact quantitative flexibility, allowing precise weighing and formulation across diverse analytical and assay setups.

What Industrial Chemical Users Look For

When commercial procurement managers, industrial chemists, and laboratory directors source bulk Coluracetam powder and raw chemical inventory, core specifications include:

1. Verified Chemical Purity & COA Document: Complete lot characterization via NMR and HPLC to confirm exact molecular structure and freedom from residual synthesis precursors or heavy metal contamination.

2. Scalable Wholesale Supply: Uninterrupted supply chain pipelines capable of providing bulk raw powder shipments for industrial formulation and contract research.

3. Crystalline Integrity & Hygroscopic Protection: Processed and packaged under controlled humidity conditions to prevent clumping, physical degradation, or atmospheric moisture absorption.

4. Batch-to-Batch Uniformity: Strict quality control standards ensuring identical melting point, solubility, and particle size distribution across all production lots.

5. Chain-of-Custody Logistics: Secure domestic shipping pipelines with moisture-proof, UV-protected packaging to guarantee compound integrity upon arrival.

Key Applications in Research & Industrial Settings

• Choline Transport & CHT1 Kinematic Assays: Measuring high-affinity choline uptake rates and $V_{\max}$ velocity shifts in presynaptic membrane fractions.

• Cholinergic Deficit & Memory Models: Evaluating acetylcholine synthesis recovery in pharmacologically depleted neuronal cell lines.

• AMPA Receptor Modulation Profiling: Investigating cross-talk between cholinergic stimulation and glutamatergic AMPA receptor expression.

• Analytical Reference Standard: Utilizing pure 1-gram samples for developing LC-MS/MS quantitative assays and purity verification protocols.

Bulk Ordering and Quality Assurance

registeredpeptides.co provides commercial clients and research facilities direct access to high-grade chemical supply backed by batch-specific analytical testing. Every production lot of Coluracetam Powder (1 Gram) undergoes third-party testing to uphold strict quality control standards.

To request current batch Certificates of Analysis (COA), inquire about custom bulk packaging, or secure tiered volume pricing, contact our chemical distribution team today.