7,8-Dihydroxyflavone – Powder, 1 gram

Description

High-Purity 7,8-Dihydroxyflavone Powder (1 Gram): Industrial-Grade Bulk Supply

Procuring small-molecule neurotrophic mimetics and selective receptor agonists requires precise chemical characterization, strict flavonoid purity standards, and complete analytical verification. registeredpeptides.co supplies industrial-grade 7,8-Dihydroxyflavone Powder (1 Gram) engineered to support scalable enterprise procurement, neurochemical assays, and institutional laboratory research protocols.

We support chemical distributors, enterprise laboratories, and high-volume purchasers who demand strict chemical specifications, verified purity profiles, and dependable supply chain logistics.

Key Specifications & Chemical Profile

• Chemical Name: 7,8-dihydroxy-2-phenylchromen-4-one

• Synonyms: 7,8-Dihydroxyflavone, 7,8-DHF

• CAS Number: 38183-03-8

• Molecular Formula: $\text{C}_{15}\text{H}_{10}\text{O}_4$

• Molecular Weight: $254.24\text{ g/mol}$

• Unit Format: 1 Gram (Pure Crystalline Solid / Raw Powder)

• Purity Rating: Verified $\ge 98\%$ via High-Performance Liquid Chromatography (HPLC)

• Grade: High-purity industrial, commercial, and laboratory reference standard

Compound Overview & Technical Mechanism

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring monomeric monomeric polyphenol derivative that functions as a potent, small-molecule mimetic of brain-derived neurotrophic factor (BDNF). Unlike full-length recombinant BDNF proteins, which exhibit poor blood-brain barrier permeability and short plasma half-lives, 7,8-DHF crosses cellular membranes effectively while maintaining high target receptor selectivity.

In laboratory, neurochemical, and bio-assay research, 7,8-DHF displays a distinct neurotrophic mechanism:

• Tropomyosin Receptor Kinase B (TrkB) Agonism: High-affinity binding to the extracellular domain of TrkB receptors dimerization and autophosphorylation.

• Downstream Neurotrophic Cascade Activation: Activates intracellular signaling cascades including MAPK/ERK, PI3K/Akt, and PLC$\gamma$1, driving neuronal survival, neurite outgrowth, and synaptic plasticity.

• Antioxidant & Cytoprotective Activity: Scavenges reactive oxygen species (ROS) and protects neuronal cell cultures from glutamate-induced excitotoxicity and oxidative stress.

The 1-gram pure powder format provides exact quantitative flexibility, allowing precise weighing and formulation across diverse analytical and assay setups.

What Industrial Chemical Users Look For

When commercial procurement managers, industrial chemists, and laboratory directors source bulk 7,8-Dihydroxyflavone powder and raw chemical inventory, core specifications include:

1. Verified Chemical Purity & COA Document: Complete lot characterization via Mass Spectrometry (MS), NMR, and HPLC to confirm exact molecular structure, polyphenolic integrity, and freedom from unreacted precursors or heavy metals.

2. Scalable Wholesale Supply: Uninterrupted supply chain pipelines capable of providing bulk raw powder shipments for industrial formulation and contract research.

3. Crystalline Stability & Oxidation Control: Processed and packaged under controlled atmospheric conditions to prevent polyphenol oxidation, phenolic group degradation, or moisture absorption.

4. Batch-to-Batch Uniformity: Strict quality control standards ensuring identical melting point, solubility profiles, and particle size distribution across all production lots.

5. Chain-of-Custody Logistics: Secure domestic shipping pipelines with moisture-proof, UV-protected packaging to guarantee compound integrity upon arrival.

Key Applications in Research & Industrial Settings

• TrkB Phosphorylation & Signaling Assays: Measuring intracellular Akt and ERK kinase activation dynamics in neuronal cell lines.

• Synaptic Plasticity & Dendritic Spine Studies: Evaluating hippocampal long-term potentiation (LTP) and dendritic remodeling parameters in vitro.

• Excitotoxicity Protection Models: Benchmarking cell survival rates under glutamate toxicity and oxidative challenge conditions.

• Analytical Method Validation: Utilizing pure 1-gram reference standards for developing HPLC and LC-MS/MS quantitative detection protocols.

Bulk Ordering and Quality Assurance

registeredpeptides.co provides commercial clients and research facilities direct access to high-grade chemical supply backed by batch-specific analytical testing. Every production lot of 7,8-Dihydroxyflavone Powder (1 Gram) undergoes third-party testing to uphold strict quality control standards.

To request current batch Certificates of Analysis (COA), inquire about custom bulk packaging, or secure tiered volume pricing, contact our chemical distribution team today.