High-Purity LL-37 (CAP-18) 5mg: Industrial & Laboratory Grade Bulk Supply

Securing high-purity, batch-tested host-defense peptides is fundamental for advanced innate immunity research, biofilm inhibition testing, and specialized industrial synthesis. registeredpeptides.co supplies industrial-grade LL-37 (CAP-18) 5mg (1 vial) designed to fulfill scalable enterprise procurement and commercial laboratory requirements.

We support chemical distributors, institutional researchers, and commercial facilities with synthetic host-defense peptides that emphasize sequence fidelity, batch consistency, and full analytical compliance.

Key Specifications & Chemical Profile

Chemical Name: Cathelicidin Antimicrobial Peptide LL-37 / hCAP-18 Fragment (134-170)
Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
CAS Number: 154947-66-7
Molecular Formula: $\text{C}_{205}\text{H}_{340}\text{N}_{60}\text{O}_{53}$
Molecular Weight: $4493.33\text{ g/mol}$
Unit Format: 5mg per vial (Lyophilized sterile solid)
Purity Rating: Verified $\ge 98\%$ via High-Performance Liquid Chromatography (HPLC)
Grade: High-purity industrial and research reference standard

Compound Overview & Technical Mechanism

LL-37 is the sole human member of the cathelicidin family of host-defense peptides, cleaved from the C-terminal domain of human cationic antimicrobial protein 18 (hCAP-18). Structurally characterized as an amphipathic alpha-helical peptide carrying a net positive charge (+6 at neutral pH), LL-37 exhibits high biological activity across multiple innate immune pathways.

In laboratory and industrial bio-assays, LL-37 functions via dual direct membrane disruption and complex immunomodulatory signaling:

Membrane Interaction & Pore Formation: Electrostatic binding to negatively charged bacterial lipopolysaccharides (LPS) and phospholipids disrupts microbial cell membranes.
Biofilm Inhibition: Inhibits quorum sensing and bacterial cell adhesion, preventing the formation of persistent microbial biofilms.
Receptor-Mediated Immunomodulation: Interacts with Formyl Peptide Receptor-Like 1 (FPRL-1/FPR2) and Toll-like receptors (TLRs) to modulate cytokine expression, chemotaxis, and cellular proliferation pathways.

The freeze-dried 5mg vial format ensures exact quantitative handling and rapid reconstitution, minimizing mass variance across multi-trial experimental runs.

What Industrial Chemical Users Look For

When commercial procurement managers, industrial chemists, and laboratory directors source bulk antimicrobial peptides and chemical compounds, core requirements include:

Verified Analytical Purity: Full lot characterization via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify exact target mass and sequence identity.
Scalable Master Ordering: High-volume inventory access ensuring project continuity and bulk delivery schedules for commercial facilities.
Vacuum Lyophilization & Thermal Stability: Vacuum freeze-drying prevents peptide hydrolysis, oxidation, and structural degradation during transit and storage.
Batch-to-Batch Mass Accuracy: Controlled quantitative filling guarantees exact unit mass allocation across single-vial or master-pack orders.
Chain-of-Custody & Fast Logistics: Reliable domestic shipping pipelines equipped with protective, temperature-managed packaging to maintain material integrity.

Key Applications in Research & Industrial Settings

In Vitro Antimicrobial & Antifungal Screening: Evaluating minimum inhibitory concentration (MIC) values across Gram-positive and Gram-negative reference bacterial strains.
Biofilm Disruption Models: Measuring structural degradation of established microbial matrices and quorum sensing inhibition.
Inflammatory & Chemotactic Assays: Quantifying immune cell migration, chemokine secretion, and TLR pathway modulation in cell cultures.
Epithelial Barrier & Angiogenesis Research: Investigating cellular repair, migration velocity, and microvascular tube formation in endothelial and keratinocyte models.

Bulk Ordering and Quality Assurance

Partnering with registeredpeptides.co provides commercial enterprises and institutional facilities direct access to high-grade chemical supply supported by batch-specific analytical testing. Every lot of LL-37 (CAP-18) 5mg is verified to maintain exact purity and structural standards across all commercial shipments.

To request current batch Certificates of Analysis (COA), place bulk volume orders, or set up custom enterprise accounts, contact our chemical distribution department directly.

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LL-37 (CAP-18) 5 mg (1 vial)